The Faculty of Science at Wasit University discussed a Doctoral thesis on the evaluation of physiological and immune biomarkers and the role of genetic variation of the gene peptaidargenine diminiz IV (PADI4) in women with rheumatoid arthritis in Wasit province for student Tamara Hamad Ahmed aims Thesis to assess the role of certain immune standards such as TNF and IL-17A, examine the effect of oxidative stress on DNA damage and the role of antioxidants in the disease, determine the role of genetic variation of padi4 SNP 163 and find the relationship between these biomarkers when Patients found that high levels of IL17 and TNF contribute significantly to the process of chronic inflammation in patients with rheumatoid arthritis, as well as ACCP and RF act as important diagnostic indicators for patients and this is considered a major risk factor associated with the viability and severity of rheumatoid arthritis